Hideaki Hara Selected Research

Retinal Diseases

5/2022	Retinal damage alters gene expression profile in lacrimal glands of mice.
1/2022	Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model.
1/2018	Involvement of cannabinoid receptor type 2 in light-induced degeneration of cells from mouse retinal cell line in vitro and mouse photoreceptors in vivo.
1/2018	[Establishment of retinal disease models using non-human primates and its strategy for drug discovery].
1/2017	Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).
1/2016	Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases.
4/2015	TUDCA Promotes Phagocytosis by Retinal Pigment Epithelium via MerTK Activation.
3/2015	Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage.
11/2013	The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage.
1/2013	Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo.

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Hideaki Hara Research Topics

Disease

31	Ganglion Cysts (Ganglion) 01/2021 - 12/2002
27	Ischemia 01/2022 - 12/2002
26	Brain Ischemia (Cerebral Ischemia) 01/2020 - 01/2005
21	Retinal Diseases 05/2022 - 01/2004
19	Glaucoma 01/2021 - 01/2004
15	Macular Degeneration (Age-Related Maculopathy) 02/2022 - 02/2011
15	Retinal Degeneration 10/2021 - 10/2010
14	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 08/2006
14	Infarction (Infarctions) 01/2020 - 03/2007
14	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/2019 - 01/2005
13	Choroidal Neovascularization 08/2021 - 09/2014
13	Retinal Neovascularization 01/2021 - 03/2007
13	Stroke (Strokes) 01/2020 - 08/2008
12	Neoplasms (Cancer) 04/2022 - 11/2009
12	Brain Injuries (Brain Injury) 02/2022 - 08/2008
10	Retinal Vein Occlusion 01/2022 - 01/2017
9	Papilledema 01/2022 - 06/2017
9	Inflammation (Inflammations) 07/2021 - 08/2013
9	Reperfusion Injury 01/2020 - 03/2006
9	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020 - 10/2011
9	Ischemic Stroke 01/2020 - 01/2011
8	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2021 - 04/2007
8	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2021 - 05/2016
8	Melanoma (Melanoma, Malignant) 01/2017 - 04/2004
7	Glioblastoma (Glioblastoma Multiforme) 04/2022 - 12/2016
7	Hypoxia (Hypoxemia) 01/2022 - 08/2006
7	Neuroblastoma 01/2015 - 10/2006
6	Macular Edema 01/2022 - 08/2006
6	Atrophy 01/2021 - 12/2010
6	Hemorrhage 01/2021 - 10/2010
6	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 12/2020 - 02/2016
6	Retinal Perforations 01/2017 - 08/2006
6	Cerebral Infarction 07/2011 - 06/2007
5	Alzheimer Disease (Alzheimer's Disease) 02/2021 - 11/2004
5	Hematoma 01/2021 - 01/2017
5	Blindness (Hysterical Blindness) 01/2021 - 02/2011
5	Hemorrhagic Stroke 01/2021 - 04/2011
5	Pathologic Neovascularization 01/2021 - 08/2009
5	Hyperoxia 05/2011 - 01/2008
4	Fibrosis (Cirrhosis) 01/2022 - 07/2018
4	Ocular Hypertension (Glaucoma, Suspect) 01/2022 - 07/2004
4	Edema (Dropsy) 01/2022 - 06/2010
4	Eye Diseases (Eye Disease) 01/2021 - 10/2010
4	Brain Edema (Cerebral Edema) 01/2020 - 12/2010
4	Constipation 10/2012 - 01/2010
4	Stomach Ulcer (Gastric Ulcer) 10/2012 - 08/2010
3	Mitochondrial Diseases (Mitochondrial Disease) 12/2021 - 01/2020
3	Glioma (Gliomas) 01/2021 - 12/2016
3	Cerebral Hemorrhage 11/2018 - 01/2017

Drug/Important Bio-Agent (IBA)

51	Retinaldehyde (Retinal)IBA 05/2022 - 12/2002
25	Neuroprotective AgentsIBA 01/2022 - 05/2005
21	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 08/2009
17	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2006
16	Pharmaceutical PreparationsIBA 01/2021 - 01/2004
15	Oxygen (Dioxygen)IBA 01/2021 - 01/2007
13	N-Methylaspartate (NMDA)IBA 08/2013 - 08/2005
10	Cilostazol (Pletal)FDA LinkGeneric 01/2017 - 03/2009
10	TunicamycinIBA 01/2015 - 10/2006
9	ProgranulinsIBA 03/2022 - 08/2013
8	AntioxidantsIBA 12/2021 - 01/2010
7	Free Radical ScavengersIBA 01/2021 - 05/2009
7	EdaravoneIBA 11/2017 - 08/2008
7	Glycoproteins (Glycoprotein)IBA 01/2017 - 01/2012
6	astaxanthine (astaxanthin)IBA 09/2020 - 10/2008
6	IgA receptor (protein B)IBA 01/2017 - 01/2012
6	Propolis (Bee Bread)IBA 10/2012 - 01/2005
6	Ethanol (Ethyl Alcohol)IBA 08/2012 - 07/2009
5	Collagenases (Collagenase)FDA Link 01/2021 - 07/2016
5	Indicators and Reagents (Reagents)IBA 04/2015 - 12/2006
5	Glucose (Dextrose)FDA LinkGeneric 09/2014 - 01/2007
4	CytokinesIBA 01/2021 - 03/2006
4	IronIBA 01/2021 - 12/2014
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2009
4	Hemoglobins (Hemoglobin)IBA 01/2020 - 10/2010
4	Tight Junction ProteinsIBA 01/2019 - 02/2013
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2018 - 03/2006
4	Warfarin (Coumadin)FDA LinkGeneric 01/2017 - 10/2013
4	Biological ProductsIBA 01/2017 - 08/2010
4	ZincIBA 02/2015 - 01/2008
4	Type 3 Cyclic Nucleotide PhosphodiesterasesIBA 10/2013 - 12/2010
4	LaxativesIBA 10/2012 - 02/2008
4	Glutamic Acid (Glutamate)FDA Link 06/2012 - 12/2002
4	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 12/2011 - 01/2009
3	4- (4- acetylpiperazin- 1- yl)- 2- (1H- imidazol- 1- yl)anilineIBA 01/2021 - 01/2016
3	Superoxide Dismutase-1IBA 01/2020 - 07/2013
3	DNA (Deoxyribonucleic Acid)IBA 11/2019 - 01/2012
3	trans-sodium crocetinate (crocetin)IBA 01/2019 - 01/2011
3	Protein Isoforms (Isoforms)IBA 01/2018 - 12/2012
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 09/2017 - 04/2011
3	Kallikreins (Kallikrein)IBA 06/2017 - 09/2014
3	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2017 - 03/2009
3	SolutionsIBA 10/2016 - 06/2010
3	Tissue Plasminogen Activator (Alteplase)FDA Link 07/2016 - 01/2011
3	Sigma-1 ReceptorIBA 03/2015 - 05/2013

Therapy/Procedure

24	Therapeutics 01/2022 - 11/2004
21	Lasers (Laser) 07/2021 - 07/2004
9	Oral Administration 01/2022 - 08/2011
5	Light Coagulation 01/2017 - 07/2004
4	Intravitreal Injections 01/2021 - 08/2005
4	Ligation 11/2016 - 12/2011